Abstract

MARTINEZ, Miguel et al. Moderate and Severe Psoriasis Vulgaris: therapy options(conventional therapies). Arch. Med Int [online]. 2013, vol.35, n.3, pp.93-100. ISSN 0250-3816.

Psoriasis is a common worldwide disease and is considered of immune affiliation. In Europe and the U.S. population reported a prevalence of 0.6 to 4%. There are no reports of Uruguay prevalence. The classic presentation is vulgar plates. Although in most cases the disease is paucisymptomatic and topical therapies allows control (mild psoriasis), in a significant proportion can severely affect quality of life associated with generalized psoriasis or involvement of other organs. Even lead to death. The main objective of this article is to provide unified guidelines on the treatment of chronic plaque psoriasis with moderate to severe presentation. This part discusses systemic ‘conventional’ treatments, giving priority to phototherapy, methotrexate, cyclosporin A and retinoids. The so called ‘Biologic Therapies’ wich are already conventional alternatives in developed countries, will be the subject of Part II of these recommendations.

Keywords : Moderate and severe psoriasis vulgaris; Psoriasis treatment; Phototherapy; Methotrexate; Cyclosporine A; Acitretin.

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