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Archivos de Medicina Interna

Print version ISSN 0250-3816On-line version ISSN 1688-423X

Abstract

ACLE, Santiago; ANON, Ximena; DANZA, Álvaro  and  PISABARRO, Raúl. Addison’s disease as the mode of presentation of a type 2 pluriglandular syndrome. Arch. Med Int [online]. 2011, vol.33, n.3, pp.65-69. ISSN 0250-3816.

Polyglandular autoimmune syndromes are defined by the coexistence of at least two glandular deficiencies resulting from the loss of immune tolerance. There are 4 types, being type 2 the most frequently seen. The presence of primary adrenal insufficiency is essential to make diagnosis of type 2 polyglandular autoimmune syndrome, and it may precede the other two endocrinopathies that compose it: autoimmune thyroid disease and/or diabetes mellitus type 1. Primary adrenal insufficiency is characterized by deficient production of adrenal cortisol, mineralocorticoids and androgens. It is a rare disease that usually occurs in middle-aged women being autoimmune adrenalitis its most prevalent etiology. In this article, we discuss the case of a 35 year old patient who complained of skin hyperpigmentation and presyncopal episodes as presentation of an Addison disease. The patient also presented amenorrhea of 8 years of evolution and a grade II goiter which led us to the diagnosis of a polyglandular autoimmune syndrome type 2

Keywords : Autoimmune polyglandular syndromes; primary adrenal insufficiency autoimmune thyroid diseases; type 1 diabetes mellitus.

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