SciELO - Scientific Electronic Library Online

vol.32 issue2-3Community-Acquired Acute Pneumonias in the Adult. Controlled Therapeutic Study: Uruguay author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links


Archivos de Medicina Interna

Print version ISSN 0250-3816On-line version ISSN 1688-423X


PISABARRO, Raúl. Statins: a therapeutic revolution underway for the treatment of cardiovascular disease. Arch. Med Int [online]. 2010, vol.32, n.2-3, pp.36-40. ISSN 0250-3816.

Summary No other drugs to date have demonstrated better reductions of cardiovascular disease than statins. This review underlines the continuous evolution of thresholds of LDL-C based on the data of new relevant studies. The actual evidence suggests that the concept of individual cardiovascular risk is likely to dictate the decision on initiating statins treatment rather than simply basing it on individual LDL-C levels. It has also been suggested that there may be no therapeutic threshold for LDL-C reduction beyond which cardiovascular benefit may not be achieved. For secondary prevention intensive therapy is safe and arrests atherosclerosis and provides further clinical benefit with CV risk reduction and hospitalizations for heart failure. In the early phase of acute coronary syndromes (first 10 days), high-doses of statins provide an early and significant reduction in the CV risk. A review of severe side effect of statin underlines their extreme rareness.

Keywords : Statins; LDL-C; Cardiovascular disease; Cardiovascular risk.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License