Abstract

VACAREZZA CONSANI, Mariela et al. Community-Acquired Acute Pneumonias in the Adult. Controlled Therapeutic Study: Uruguay. Arch. Med Int [online]. 2010, vol.32, n.2-3, pp.31-35. ISSN 0250-3816.

Summary The objective of the current research was to investigate the efficacy of and tolerance to aminopenicillins, compared with other agents usually prescribed in Uruguay for the treatment of Community-Acquired Acute Pneumonias in outpatients and inpatients. After applying due exclusion criteria, an accumulative strategy was used to enroll a population of 100 subjects older than 18 years from all the patients that presented with community-acquired acute pneumonias from May 1 to October 31 2004 at the Clinicas Hospital in Montevideo. It was a controlled, randomized single blind trial (for inpatients) and double blind (for outpatients), in one hospital alone. We compared the potential differences of the means independent of the clinical variables between two groups of inpatients, some treated with ceftriaxone and others with amoxicillin-clavulanic acid. The same comparison was made between the two groups of outpatients, some treated with clarithromycin and others with amoxicillin. The level set for statistical significance was p<0.05. We analyzed the differences between the same groups in the variables “clinical-radiological cure at thirty days” and “drug intolerances”, using statistical significance tests for differences of two independent proportions (p< 0.05). Clinical and radiological cure was achieved both in inpatients and outpatients within thirty days of having started therapy, with no significant differences in the final outcomes. In the case of the inpatients, those treated with amoxicillin - clavulanic acid reached a better clinical improvement at the third day than those on ceftriaxone (P<0.05). No statistically significant differences were found for drug intolerance, either in outpatients or in inpatients.

Keywords : Adult Community-Acquired Acute Pneumonia; Therapy; Aminopenicillins.

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