Abstract

BUENO, Adrián Marcelo  and  DE OLMOS, Soledad. The use of the pharmacological model based on the experimental administration of MK-801, for the revision and redefinition of the limbic system into the anatomical and pathological context. Cienc. Psicol. [online]. 2009, vol.3, n.1, pp.83-90. ISSN 1688-4221.

The neuro-toxic effect induced in the rat limbic system after acute MK-801-treatment, affects all the limbic lobe areas, such as olfactory cortex, basolateral amygdala, hippocampal system, cingulate cortex and specific frontal and insular cortical region (allo-cortical and meso-cortical areas). In contrast, the sub-cortical nucleus usually included into the limbic system, such as the extended amygdala, the estriato-pallidal-ventral system, septal area, thalamus and hippothalamus, do not evidentiate neural death. Anatomo-pathological results suggest that the limbic lobe areas share common characteristics, and support the idea of a different functional unit, which differs from other sub-cortical “limbic” regions. This supports the idea of a limbic lobe formed only by thelencephalic allo-cortical and meso-cortical areas and implies the need to redefine the classic and broad concept of “limbic system”

Keywords : MK-801; Neuronal death; Limbic System; Neuropathologic model.

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