Abstract

GRUNBERG, Gustavo. OMEPRAZOL PARA LA REDUCCIÓN DEL RIESGO DE DESARROLLO DE SINDROME DE MENDELSON EN PACIENTES COORDINADOS PARA CIRUGÍA ABDOMINAL. Anest Analg Reanim [online]. 2003, vol.18, n.1. ISSN 1688-1273.

The aim of this study was to measure the gastric volume and acidity reduction produced by preoperative administration of Omeprazole. We realized a prospective, randomized, double blind study in patients undergoing elective abdominal surgery under general anesthesia. 22 patients of both genders, ASA I-III, 18 years or older were randomly assigned to receive either Omeprazole 40 mg or placebo orally the night before surgery. After tracheal intubation pH and volume of gastric juice were measured. In Omeprazole group pH was 4.86 ± 2.37 (mean ± SD) and in placebo group 2.19 ± 1.77 (p = 0.004). The incidence of patients with pH £ 2.5 in Omeprazole group was 27% and in Placebo group was 80% (Relative Risk (RR) = 0.34 IC95% 0.12-0.94). The mean gastric volume found in Omeprazole group was 24.18 ml ± 18.03 ml and in placebo group 30.45 ml ± 25.54 ml (p = 0.26). The incidence of patients with volume ³ 25 ml was similar in both groups (RR = 0.91 IC95% 0.37-2.23). We concluded that Omeprazole 40 mg orally effectively reduced gastric acidity and therefore the risk for Mendelson Syndrome, with a significant reduction of the number of patients with pH £ 2.5 (RR Reduction (RRR) = 66% IC95% 88-6%). The mean gastric volume found was higher in placebo group than Omeprazole group, but the results were not statistically significant between groups. The number of patients with a volume ³ 25 ml was not significantly reduced.

Keywords : Omeprazole; Mendelson Syndrome; Abdominal Surgery; General Anesthesia.

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