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Archivos de Pediatría del Uruguay

Print version ISSN 0004-0584On-line version ISSN 1688-1249


AMARO, Verónica; AKIKI, Anabel; MOREIRA, Isabel  and  PINCHAK, Catalina. Characteristics of patients with severe and difficult-to-control asthma assisted at the Pediatric Pneumology Department of the Pereira Rossell Children Hospital Center. Arch. Pediatr. Urug. [online]. 2021, vol.92, n.1, e207.  Epub June 01, 2021. ISSN 0004-0584.


asthma is the most frequent chronic respiratory disease in children. Severe asthma accounts for less than 5% of all pediatric asthma cases, and shows high morbidity rates, healthcare costs, and even mortality.


to analyze the clinical and functional characteristics, and comorbidities of patients with severe asthma.

Material and methods:

descriptive, analytical, retrospective, and transversal study on patients with severe asthma, treated at Pereira Rossell Children Hospital Center between 1/1/2019 and 1/1/2020. Inclusion criteria: children and adolescents of between 5 and 15 years of age with a diagnosis of severe and difficult-to-treat asthma.


15 patients included, 9 females, with a mean age of 10.4 years. All patients showed an early onset of symptoms, beginning at preschool age. 8/15 patients’ first-degree relatives had a record of asthma. Tobacco exposure was present in 8/15. Adherence was correct in 6/15. The inhalation technique was adequate in 11/15. Allergic rhinitis was the most frequent comorbidity assessed, present in 12 out of 15 cases, while obesity was present in 3 out of 15 cases.


in the period analyzed, severe asthma accounts for 3.8% of all asthma cases. Most were difficult-to-treat asthma cases (11/15) due to underlying modifiable or reversible factors that prevent asthma control.

Keywords : Asthma; Drug resistance.

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