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Archivos de Pediatría del Uruguay

versão impressa ISSN 0004-0584versão On-line ISSN 1688-1249


DENDI, Álvaro; MATTOS, María José; SOBRERO, Helena  e  MORAES, Mario. Case studies of patients with connatal symptomatic cytomegalovirus infection at the Pereira Rossell Children Hospital. Arch. Pediatr. Urug. [online]. 2019, vol.90, n.6, pp.328-334.  Epub 01-Dez-2019. ISSN 0004-0584.


cytomegalovirus is a greatly prevalent connatal infection and it is the most common cause of non-genetic sensorineural hearing loss. Mostly, in up to 90% of the cases, is asymptomatic. There is few data in Uruguay regarding its epidemiology.


to learn about the symptomatic connatal cytomegalovirus epidemiological profile at the Pereira Rossell Children Hospital.

Materials and methods:

descriptive transversal longitudinal study. Source of data: electronic medical records. Selection criteria: hospitalized newborns between Jan 1, 2010 and Dec 31,2018 showing a polymerase chain reaction (PCR) for positive cytomegalovirus in urine, saliva or blood during the first 3 weeks of life and at least one clinical or paraclinical reaction.


19 patients met the criteria. Incidence: 0,2/1000 of live newborns. Two patients died. A blood or urine PCR test was carried out. The most common clinical symptoms were: small-sized babies for their gestational age, microcephaly, hepatosplenomegaly. Paraclinical alterations: imagological SNC alterations, hematological alterations and hepatogram alterations. Ganciclovir treatment was started in every case, but treatment duration and continuity were heterogeneous.


the findings regarding symptomatic connatal cytomegalovirus prevalence and their clinical and paraclinical symptoms met the international literature findings. It is essential to create a patient management protocol for patients with connatal cytomegalovirus.

Palavras-chave : Cytomegalovirus; Ganciclovir; Newborn.

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