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Archivos de Pediatría del Uruguay

versão impressa ISSN 0004-0584versão On-line ISSN 1688-1249

Resumo

DENDI, Álvaro; MATTOS, María José; SOBRERO, Helena  e  MORAES, Mario. Case studies of patients with connatal symptomatic cytomegalovirus infection at the Pereira Rossell Children Hospital. Arch. Pediatr. Urug. [online]. 2019, vol.90, n.6, pp.328-334.  Epub 01-Dez-2019. ISSN 0004-0584.  https://doi.org/10.31134/ap.90.6.5.

Introduction:

cytomegalovirus is a greatly prevalent connatal infection and it is the most common cause of non-genetic sensorineural hearing loss. Mostly, in up to 90% of the cases, is asymptomatic. There is few data in Uruguay regarding its epidemiology.

Objective:

to learn about the symptomatic connatal cytomegalovirus epidemiological profile at the Pereira Rossell Children Hospital.

Materials and methods:

descriptive transversal longitudinal study. Source of data: electronic medical records. Selection criteria: hospitalized newborns between Jan 1, 2010 and Dec 31,2018 showing a polymerase chain reaction (PCR) for positive cytomegalovirus in urine, saliva or blood during the first 3 weeks of life and at least one clinical or paraclinical reaction.

Results:

19 patients met the criteria. Incidence: 0,2/1000 of live newborns. Two patients died. A blood or urine PCR test was carried out. The most common clinical symptoms were: small-sized babies for their gestational age, microcephaly, hepatosplenomegaly. Paraclinical alterations: imagological SNC alterations, hematological alterations and hepatogram alterations. Ganciclovir treatment was started in every case, but treatment duration and continuity were heterogeneous.

Conclusions:

the findings regarding symptomatic connatal cytomegalovirus prevalence and their clinical and paraclinical symptoms met the international literature findings. It is essential to create a patient management protocol for patients with connatal cytomegalovirus.

Palavras-chave : Cytomegalovirus; Ganciclovir; Newborn.

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