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Archivos de Pediatría del Uruguay

Print version ISSN 0004-0584On-line version ISSN 1688-1249


BARRIOS, Patricia et al. Vertical transmission of Toxoplasma gondii infections: follow up of children born to mothers diagnosed with a primary infection in a healthcare center between 2010 and 2015. Arch. Pediatr. Urug. [online]. 2016, vol.87, suppl.1, pp.S20-S25. ISSN 0004-0584.

Congenital toxoplasmosis (CT) affects one to two children out of 1000 births per year. Most infected newborns present no symptoms, although the absence of treatment may result in eye and neurologic sequelae. Objective: to describe follow-up of children born to mothers diagnosed with a primary Toxoplasma gondii infection during pregnancy referred to an Infectology Policlinic of Medica Uruguaya between December, 2010 and May, 2015. Method: the children of women with Toxoplasma gondii primary infection during pregnancy between December 1, 2010 and May 31, 2015 were included in the study. Primary infection was confirmed through specific IgG and IgM immunoenzymatic techniques, complemented by IgM by indirect immunofluorescence or IgG avidity test, depending on the case. Diagnosis of congenital infection was done according to the presence of IgM or IgG stable or increasing titers in the first 9 months of follow-up of the children. Results: thirty four women were diagnosed with primary infection. Most of them were properly controlled during pregnancy and none of them were HIV, syphilis or Chagas positive. Congenital toxoplasmosis was confirmed in 3 children delivered on the date they were due, with adequate weight, children to mothers with primary infection acquired in the third trimester and treated with spiramycin. One of them evidenced chorioretinitis and the others were asymptomatic. IgM was negative in all cases, diagnosis being confirmed with IgG curve. All of them received pyrimethamine sulfadiazine and folinic acid, there being no side effects. Today, two of the three children are still under treatment and under follow-up. Discussion and conclusion: follow-up of pregnant women since early stages of pregnancy and the timely indication of preventive measures constitute essential pillars to reduce congenital toxoplasmosis. Timely and adequate treatment may prevent sequelae.


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