Abstract

PIETRAFESA, Damian; VOMERO, Alejandra  and  GIACHETTO, Gustavo. Anticonvulsant hypersensitivity syndrome: Description of three cases. Arch. Pediatr. Urug. [online]. 2016, vol.87, n.1, pp.38-43. ISSN 0004-0584.

Toxicodermas are drug-induced dermatoses. They represent the most frequent adverse reactions to drug products. The Anticonvulsant severe hypersensitivity syndrome, or DRESS syndrome ('Drug Rash with Eosinophilia and Systemic Symptoms') is a rare, idiosyncratic, and potentially fatal toxicoderma. Anticonvulsants are its most frequent cause. In this communication, the clinical and paraclinical manifestations, as well as the diagnostic difficulties of three clinical cases are described. Its timely diagnosis requires a high degree of suspicion, the knowledge of its manifestations, and the possible differential diagnoses. Mortality is directly related with the presence of acute hepatocytic failure. Discontinuation of the drug product involved is fundamental. The importance of evaluating the benefit-risk ratio when prescribing a drug product, and of incorporating pharmacovigilance into clinical practice is highlighted.

Keywords : DRUG HYPERSENSITIVITY SYNDROME; ANTICONVULSANTS.

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