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Archivos de Pediatría del Uruguay

Print version ISSN 0004-0584On-line version ISSN 1688-1249


CAGGIANI, Marina. Systemic lupus erythematosus in children and adolescents  . Arch. Pediatr. Urug. [online]. 2015, vol.86, n.4, pp.3-3. ISSN 0004-0584.

Systemic lupus erythematosus is a chronic autoinmune disease that evolves in relapses and remissions. It can affect every tissue of the body producing diverse clinical manifestations. Twenty per cent of SLE begin during childhood and are generally more severe than in adults. The objective of this study is to describe 39 patients with SLE controlled in the Connective tissue diseases clinic of the Pereira Rossell Hospital between October 2003 and May 2014. 84.6% were female with female ratio 5.51. 80% were Caucasian. Mean age at diagnosis was 11 years. Ten percent had family history of SLE. 97.4% of SLE were severe. 82% presented constitutional symptoms and mucocutaneous manifestations, 72% had hematological compromise. Arthritis was seen in 67%, renal involvement in 51%, respiratory tract was affected in 41%. 28% presented cardiovascular compromise and 21% had neurological involvement. The liver and gastrointestinal system was affected in 18%. Mean patient follow up was 3.6 years. Complete or partial remission was accomplished in 67%. Treatment included corticosteroids and hydroxychloroquine; other inmunosupressives as azathioprine, mycophenolate and cyclophosphamide were elected depending on the clinical pattern. Mortality was 5%. Infections were the most frequent complication. Early diagnosis, an adequate treatment and follow up are needed to improve the outcome of this severe illness 


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