Abstract

PRADO, Francisco; JORQUERA, Aline  and  CASTILLO-DURAN, Carlos. Is there a relation between vitamin D deficiency and an increased risk for bronchiolitis and bronchial asthma in childhood?: A critical revision. Arch. Pediatr. Urug. [online]. 2015, vol.86, n.3, pp.208-213. ISSN 1688-1249.

We critically review the information about vitamin D deficiency (VDD) and risk of lower respiratory infections and asthma in children. Acute lower respiratory infections (ALRI), particularly those due to respiratory syncytial virus (RSV) are associated with a high burden of disease. In theabsence of a vaccine for them, prevention and support during illness are important measures to reduce the risk of acquiring the condition or decreasing its severity. VDD has been described as prevalent in all geographical environments; its consequences are linked to calcium and bone metabolism, but also to impaired immunity. Recent evidence of an association between VDD and increased risk of ALRI, especially during the first few months of life has been demonstrated; alleles of some polymorphism of vitamin D receptor may be involved in an increased risk of LRTI. It is justified to study the impact of measures of vitamin D supplementation adapted to local environments, including the appropriate doses to the mother during pregnancy and/or to the child in the first months of life, on the risk of ALRI, or asthma in later ages.

Keywords : VITAMIN D DEFICIENCY; RESPIRATORY TRACT INFECTIONS; ASTHMA; BRONCHIOLITIS; CHILD.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )