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vol.84 issue2Lesiones graves y fatales en niños y adolescentes uruguayos secundarias a siniestros de tránsito por motos: Estudio epidemiológico author indexsubject indexarticles search
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Archivos de Pediatría del Uruguay

On-line version ISSN 1688-1249


MOROSINI, Fabiana et al. Neuroblastoma en niños menores de 18 meses: Experiencia de 10 años en Centro Hematooncológico Pediátrico del Centro Hospitalario Pereira Rossell. Arch. Pediatr. Urug. [online]. 2013, vol.84, n.2, pp.84-90. ISSN 1688-1249.

Summary  Introduction: neuroblastoma is the most common malignant tumor in infants. Its clinical behavior is variable, from spontaneous regression to malignant progression; prognostic factors are multiple, such as age, stage, N-myc amplification and tumor ploidy. We describe the characteristic of all patients with neuroblastoma less than 18 months of age assisted in CHOP. Patients and methods: retrospective, observational and descriptive study in the period between 31/1/00 y 31/01/11. Diagnose was made from histology and bone marrow aspirate. Patients were classified by INSS stage; treatment was decided according to stage and risk. Results: 22 patients were included (52% of all neuroblastomas), with a mean age of 9,6 months. Eleven patients were classified in stage 4. The most frequent localization was adrenal; 14 patients presented methastasis. Fifteen patients received chemotherapy and 20 were surgically intervened. N-myc amplification was detected in 3 patients. Overall survival was 77% and event-free survival was 77%. Discussion and conclusions: the majority of cases were diagnosed in children younger than 9 months. Stages 4 and 1 were the most frequent. No association between N-myc and stage could be determined. Overall and event-free survival were excellent


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