Abstract

AGUIRRE, Mey et al. Síndrome de Cushing secundario a interacción medicamentosa ritonavir/fluticasona . Arch. Pediatr. Urug. [online]. 2012, vol.83, n.1, pp.21-25. ISSN 1688-1249.

Summary  We present 3 cases of children infected with human immunodeficiency virus (treated with ritonavir / lopinavir, zidovudine and lamivudine) and persistent asthma, and/or allergic rhinitis (treatment with inhaled fluticasone propionate or intranasal) that later have concomitant therapy, weight gain, moon face, and stretch marks on thighs. In case 1 the diagnosis did not achieve clinical laboratory confirmation. In cases 2 and 3, the serum cortisol and ACTH were consistent with adrenal suppression. In case 1 after discontinuation of fluticasone physical examination was normal at 6 months. In case 2 after stopping fluticasone clinical examination was normal at 6 months, no paraclinical performing. In case 3 to 6 months of ritonavir exchange of clinical regression and normalization of ACTH and cortisol levels was evident. This confirms iatrogenic Cushing's syndrome secondary to ritonavir drug interaction/fluticasone

Keywords : CUSHING SYNDROME; HIV INFECTIONS; ASTHMA; RITONAVIR-adverse effects; ADRENAL CORTEX HORMONES-adverse effects; DRUG INTERACTIONS.

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