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Archivos de Pediatría del Uruguay

On-line version ISSN 1688-1249


BARROS COSTA, Mônica; DANTAS GOUVEA, Ester; FERREIRA VARGAS, Lize  and  MOREIRA LANNA, Carla M. Adrenarquia precoz y marcadores del síndrome metabólico. Arch. Pediatr. Urug. [online]. 2008, vol.79, n.3, pp.196-200. ISSN 1688-1249.

Summary Introduction: precocious adrenarche (PA) can be associated with dislipidemia, hyperinsulinemia and hypertension, in adult age. Objectives: to evaluate clinical and laboratory characteristics in the metabolic syndrome in the PA patients. Patients and method: we evaluated 51 brazilian girls: 30 with PA and 21 normal girls. Results: abdominal circumference (65,2±11,2 cm versus 46,2±17,6 cm), systolic blood pressure (111,3±12,3 mmHg versus 98,8±11,4 mmHg) and diastolic blood pressure (71,8±9,2 versus 65,0±8,1 mmHg), were higher in the PA group (p<0,05). HDL levels were lower in the PA group (40,9±8,3 versus 43,7±5,7 (p=0,020). Insulin (9,0±5,0 mUI/ml versus 5,2±3,0 mUI/mL), HOMA-IR index (3,2±1,4 versus 2,1±1,0), DHEA-S (594,2±288,2 ng/mL versus 285,8±213,9 ng/mL) and 17OH progesterone levels (54,9±38,9 godly versus 34,3±9,7 ng/dL) were higher in girls with PA (p<0,05). Conclusions: girls with PA usually show the presence of insulin resistance and its study is important in order to prevent metabolic syndrome in this group


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