Abstract

JUANENA, Carolina et al. Cardiovascular toxicity by rivastigmine transdermal patches. Two case report. Rev.Urug.Cardiol. [online]. 2019, vol.34, n.3, pp.173-183.  Epub Dec 01, 2019. ISSN 0797-0048.  https://doi.org/10.29277/cardio.34.3.15.

Rivastigmine, an anticholinesterase drug, improves cholinergic neurotransmission and is used in the treatment of Alzheimer’s and Parkinson’s diseases. In the Center for Information and Toxicological Advice there have been cases of intoxication due to the use of transdermal rivastigmine patches, which have increased in recent times. We present two clinical cases of acute intoxication by transdermal patches of rivastigmine in which serious cardiac arrhythmias were found, associating a decrease in plasma cholinesterase. The risks of the use of this medication are highlighted in order to be attentive to the first symptoms of intoxication, to be able to act timely and to prevent new events.

Keywords : Rivastigmine; Arrhythmias Cardiac; Cholinesterases; Chemical and Drug Induced Liver Injury.

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