Abstract

BURDIAT, Gerard et al. Prescription of statins, adherence and lipid level two years after hospitalization for coronary disease. Rev.Urug.Cardiol. [online]. 2016, vol.31, n.3, pp.398-404. ISSN 0797-0048.

Background: coronary artery disease patients should receive high intensity treatment with statins. While these drugs are prescribed to almost all of them, the doses, adherence and obtained lipid levels are quite different. Objectives: to survey statin therapy in a group of coronary patients in our institution, meet prescribed doses, compliance and lipid profile results of a 2 years follow-up. Methods: a retrospective analysis of patients 80 years consecutively hospitalized for coronary disease and included in a secondary prevention program, between 08/01/2009 and 07/31/2012 was performed. Medication compliance was obtained by telephone interview. Lipid levels were obtained from the first lipid profile after patient discharge and the last registered in the follow-up period. Results were analyzed by chi² test or t test as appropriate. Results: from a total of 1375 patients hospitalized in the period, 1208 were included. Mean follow-up was 2,1 years. 71,3% male. The mean age was 68,6 ± 10,2 years, men 66,9 ± 10,1 years, women 72,9 ± 9,0 years. 98,6% of patients received a statin after discharge and 89,8% took it two years later. Initial statin mean dose was 17,3 mg/day of atorvastatin (or equivalent) and 17,5 mg/day at the follow-up (p = 0,66). Total cholesterol (Col T) average values in the population were 164,3 ± 39,1 mg/dl at baseline and 158,6 ± 36,4 after two years (p= 0,004), while LDL-cholesterol (LDL-C) were 89,3 ± 31,2 and 83,3 ± 34,7 respectively (p= 0,005). In 36,7 % of patients LDL-C was <70 mg/dl, while in 75 % it was <100 mg/dl. Conclusions: the prescription of statins was performed in almost all patients and two years later was taken by almost 90% of them, the average dose was on moderate range and was unchanged in the follow-up. Nearly three of every four patients reported good compliance. Col-T and LDL-C population levels improved slight but significantly after two years. More than a third of patients achieved LDL-C <70 mg/dl.

Keywords : coronary disease; Statins; Lipid profile.

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