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Revista Uruguaya de Cardiología

versión impresa ISSN 0797-0048versión On-line ISSN 1688-0420


VIDAL, Inés; ESTIGARRIBIA, Jorge; BAEZ, Álvaro  y  VIDAL, Luis. Uruguayan Registry of Hypertrophic Cardiomyopathy. Rev.Urug.Cardiol. [online]. 2015, vol.30, n.3, pp.295-311. ISSN 0797-0048.

Grounds and objectives: we do not have clinical, morphological, handling or prognostic data of hypertrophic cardiomyopathy (HC) in Uruguay. To obtain them, we implemented an Uruguayan Registry of HC (RUMHI). Method: we studied a population of 52 patients with HC, with average follow-up of 31.7 ± 12.5 months. Results: with female predominance (58%) and age 6 to 82 years (50.3± 20.7), 69% present symptoms, prevailing dyspnea (54%) associated with the presence of intraventricular obstruction (p = 0, 048) and syncope, related to a family history of sudden death (p = 0.033). 13% have atrial fibrillation. Twenty-five (48%) associated arterial hypertension (AH); 23 of grade 1. They have typical echocardiographic pattern: small cavity, preserved systolic function, asymmetric left ventricular hypertrophy (LVH) (71%) and maximum thickness on the basal segments of the septum (90%). 58% present dynamic obstruction; latent was searched only in 25%. Mitral regurgitation severity was associated with dynamic left ventricular outflow tract obstruction (p=0,04). Hypertensive subjects showed no major hypertrophy nor worse Functional Class (FC). With a global mortality rate of 8.7%, significant symptomatic improvement was observed at the end of the follow-up (69% vs. 43% ; p=0,001). Conclusions: despite the limited number of patients, the RUMHI showed a Uruguayan population with HC presenting similar characteristics to those described in literature. Coexistence with AH is frequent (48%) but was not related to a greater LVH nor with worse FC. Insufficient search for latent dynamic obstruction was detected. The population followed (88.5%) showed improvement in FC, likely related to the treatment established.


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