Resumen

DIEZ, EMILIANO RAúL; PRADO, NATALIA JORGELINA; PONCE ZUMINO, AMIRA ZULMA  y  MIATELLO, ROBERTO MIGUEL. Efecto del poscondicionamiento isquémico sobre las arritmias de reperfusión en un modelo de hipertrofia miocárdica. Rev.Urug.Cardiol. [online]. 2011, vol.26, n.2, pp.101-107. ISSN 1688-0420.

Introduction: ischemic postconditioning (IPC) is a protective strategy against reperfusion injury with antiarrhythmic properties. Cardiac hypertrophy secondary to hypertension increases the risk of arrhythmias and also reduces the response to some treatments. Objective: to determine whether the antiarrhythmic effect of IPC was maintained in hypertrophic hearts. Methods: isolated rat hearts from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) of the same age, were perfused according to Langendorff technique and subjected to 15 min regional ischemia. At the moment of reperfusion, hearts were divided into: a) WKY, b) WKY-IPC, c) SHR, d) SHR-IPC (each group, n= 13). The IPC consisted of 3 cycles of 30 s of reperfusion and 30 s of ischemia at the onset of reperfusion. Ventricular arrhythmias were diagnosed using ECG records. Hypertrophy was estimated by relative heart weight. Results: hypertension in SHR induce myocardial hypertrophy. All hearts underwent a high incidence of ventricular fibrillation (SHR 92,3% and WKY 77%, ns). IPC restored sinus rhythm in the hearts of normotensive rats (WKY-PCI 61,5% versus WKY 23,1%, p = 0,0236 by C² test) and in those from SHR (SHR-PCI 69% versus SHR 15,4%, p = 0,0016 C² test). Conclusion: IPC is able to restore sinus rhythm from most of the hearts that developed reperfusion ventricular arrhythmias and the antiarrhythmic effect remains in hypertrophic hearts from SHR rats.

Palabras clave : ARRHYTHMIAS, CARDIAC; MYOCARDIAL REPERFUSION INJURY; ISCHEMIC POSTCONDITIONING; RATS, INBREAD SHR.

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