Abstract

VIDAL, INÉS  and  ANTES, ADRIÁN. Depósitos corneales secundarios al tratamiento crónico con amiodarona: frecuencia, relación con la dosis, los días de suspensión y la duración del tratamiento. Rev.Urug.Cardiol. [online]. 2009, vol.24, n.2, pp.101-104. ISSN 1688-0420.

SUMMARY Current literature states that in populations receiving uninterrupted, higher than usual –in our daily practice– doses of amiodarone, a correlation between frequency and quantity of corneal deposits against total dosage and length of treatment can be established. We therefore decided to determine frequency and quantity of amiodarone-induced corneal deposits and study their relation to dose, weekly interruptions and length of treatment. Those patients of the institution that were chronically treated by the author (IV) with amiodarone between september 1999 and september 2000, who consented to be studied with a splitlamp were included. Corneal deposits were classified as absent, very light, light, moderate or severe. The statistical analysis was conducted by using the precise Fisher test when comparing proportions, the Kruskal-Wallis test for averages between 2 or more groups and the Spearman coefficient to correlate doses with amount of deposits. A total of 21 patients (90% male) with an average of 71.3 years of age (SD=9.4) were included. In 76% of the patients corneal deposits were found. A direct correlation was found between the amount of corneal deposits and total dose of amiodarone (r=0.630; p=0.020), daily dose (r=0.706; p<0.001) and particularly the average weekly dose (r=0.731; p<0.001). Severe deposits were associated to lack of interruptions (p=0.001). However, no relation was found between deposits and length of treatment. These results would put in evidence the important influence that the periodic interruption of the drug has on this particular side effect.

Keywords : AMIODARONE; CORNEAL DEPOSITS; DOSE; LENGTH OF TREATMENT; INTERRUPTIONS.

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