Abstract

ESPINEIRA ISABELLA, MARCELO DANIEL; MILA GARCIA, RAFAEL; ALBERTI CORREA, MANUEL  and  PIRIZ ABIB, HéCTOR. Comparación del efecto cardioprotector del preacondicionamiento farmacológico con anestésicos halogenados: sevoflurano versus isoflurano in vivo. Rev.Urug.Cardiol. [online]. 2007, vol.22, n.2, pp.116-122. ISSN 1688-0420.

SUMMARY Background: halogenated anesthetics induce preconditioning and are used in cardiac surgery. They show different preconditioning effect, in part due to their distinct physical and chemical properties, animal model chosen and different concentrations, utilized. Objectives: To develop applicable strategies of myocardial protection against ischemia-reperfusion injury. To compare the preconditioning effect of sevoflurane and isoflurane in vivo. Methods: four groups of 6 Wistar rats each (n=24) were studied using a myocardial ischemia-reperfusion model with infarct produced by occlusion of the left coronary artery. Continuous hemodynamic and electrocardiographic monitoring, and histological staining of infarct and at-risk areas were performed. Ischemic preconditioning was performed by intermittent serial occlusion of the left coronary artery before the 30-minute infarct occlusion; pharmacological preconditioning was performed by intermittent exposure to volatile anesthetic before the infarct: 1 Minimal Alveolar Concentration of isoflurane and sevoflurane. Results were compared with control. Results: they are expressed as percentage of infarct area in relation to area at risk (mean ± standard deviation). Preconditioning was more evident in these areas: center- control (33,7±2,2); ischemic preconditioning (15,8±3,1); sevoflurane (21,8±1,3); isoflurane (28,3±1,3). apex- control (41,3±2,0); ischemic preconditioning (18,5±1,4); sevoflurane (26,5±1,9); isoflurane (33,9±2,3). Statistically significant differences were found between all groups with p<0.05 (ANOVA-Bonferroni). Conclusions: sevoflurane was more effective than Isoflurane in protecting against ischemia reperfusion injury. Ischemic preconditioning prove to be more protective than both halogenated anesthetics.

Keywords : ISOFLURANE; ANESTHETIC, INHALATION; MYOCARDIAL REPERFUSION INJURY.

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