Resumen

GARAFONI, Federico; LEAL, Angel  y  SPERANZA-MOURINE, Noelia. Evaluation of antibiotic consumption in intensive care as a tool to promote rational use. Rev. Méd. Urug. [online]. 2025, vol.41, n.3, e202.  Epub 16-Jun-2025. ISSN 0303-3295.  https://doi.org/10.29193/rmu.41.3.2.

This study aims to characterize antibiotic consumption and antimicrobial resistance of the most frequently isolated microorganisms in an adult intensive care unit in Montevideo during 2019, through a drug utilization study (DUS) in the private health sector. The total annual antibiotic consumption was 75.06 DDD/100 bed-days for the entire unit, with the highest consumption corresponding to the sulfonamide group (cotrimoxazole) at 25 DDD/100 bed-days, followed by cefuroxime (14 DDD/100 bed-days) and ampicillin-sulbactam (7.1 DDD/100 bed-days). The main isolated microorganisms were S. aureus, P. aeruginosa, K. pneumoniae, and E. coli. A correlation was established between antibiotic consumption and the isolated microorganisms, showing an association in at least half of the cases. This is the first published study on antibiotic consumption in adult intensive care in the country, and this type of data serves as a tool to rationalize and optimize antibiotic use.

Palabras clave : Antibiotic consumption; Drug utilization study; Irrational use; Intensive care; Critical care; Antimicrobial resistance; Multidrug resistance.

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