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Revista Médica del Uruguay

Print version ISSN 0303-3295On-line version ISSN 1688-0390


ORELLANO, Pablo  and  PERNA RAMOS, Abayubá. Limbic encephalitis associated with inappropriate secretion of antidiuretic hormone. A case report and literature review. Rev. Méd. Urug. [online]. 2023, vol.39, n.1, e701.  Epub Mar 01, 2023. ISSN 0303-3295.

Autoimmune limbic encephalitis is a rather unusual neurological condition with subacute progression and neuropsychological symptoms. Currently, acute or maintenance treatment with immunotherapy is targeted depending on the accompanying neural specific antibody and the presence or absence of cancer.

The study presents the case of a 52-year-old woman suffering from autoimmune hypothyroidism, syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) and persistent hyponatremia, with progressive evolution which involved memory loss and faciobrachial dystonic seizures (FBDS). She was timely diagnosed with limbic encephalitis and was treated with intravenous combined corticosteroids and immunoglobulin therapy. Response was good, with minimum neuropsychological.

Recognizing this condition allows for early diagnosis and treatment, what is key to improve the prognosis of these patients.

Keywords : Limbic encephalitis; Hyponatremia; Inappropriate ADH syndrome; Dementia.

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