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Revista Médica del Uruguay

Print version ISSN 0303-3295On-line version ISSN 1688-0390


RIVAS, Gabriela et al. Guidelines for the obstetric management of an alloimmune mother and her newborn. Rev. Méd. Urug. [online]. 2021, vol.37, n.3, e801.  Epub Sep 01, 2021. ISSN 0303-3295.

Alloimmunization is the biological response to exposure to non-HLA antigens. Pregnancy, transfusion of blood components, solid organ and hematopoietic cell transplantation, as well as intravenous drug use expose patients to the development of anti-erythrocyte antibodies. When the latter are found, they must match diagnostic criteria to identify the potential association to hemolytic disease of the fetus and newborn (HDFN) and its timely referral to the high-risk obstetric risk polyclinic for due follow-up.

It is of the essence for erythrocyte alloimmunization diagnostic tests to be carried out by the immunohematology laboratories of the Hemotherapy and Transfusional Medicine services. To that end, we have prepared these guidelines with the purpose of providing a multidisciplinary protocol for the handling of maternal alloimmunization and alloimmunization of the newborn.

Keywords : Isoimmunization; Hemolytic disease of the newborn; Hemolytic disease of the fetus; Laser-Doppler flowmetry; Anemia, neonatal; Pregnancy; Alloimmunization; Anti D immunoprophylaxis.

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