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Revista Médica del Uruguay

Print version ISSN 0303-3295On-line version ISSN 1688-0390


ORELLANO, Pablo et al. Silver nanoparticles to treat mycosis associated with diabetic foot. Rev. Méd. Urug. [online]. 2021, vol.37, n.1, e206.  Epub Mar 01, 2021. ISSN 0303-3295.

Onychomycosis and tinea pedis represent a significant proportion of infections in the diabetic foot, a common foot problem, and they constitute a threat to the viability of tissues that may provoke secondary bacterial infections. To combat them, antifungal treatments are required for long periods of time, the rates of relapse and reinfection being high. Several studies have proved the safety and effectiveness of silver nano particles (NP Ag) as an antimicrobial agent.

A study was conducted to assess nanoparticle agents for foot dermatomycosis in diabetic patients.


pilot, open, prospective randomized and controlled study in patients who are assisted in a diabetic foot policlinic. 18 patients complied with the inclusion criteria and two homogeneous groups were formed.

Both groups received standard treatment consisting in topic antifungal and mechanical roughing. The intervention groups used a textile (stockings) made with silver nanoparticle threads. Clinical and microbiological control was made during 12 weeks, also assessing the remission percentage and the time it took to achieve it.


onychomycosis and trichophyton rubrum prevailed. The intervention group showed a greater percentage of remission of lesions in a period of time that was shorter than that of the control group.


the use of stockings made with NP Ag threads was associated with a greater probability of complete healing, in a 12-week period, despite the fact that the number of patients was not statistically significant. This could contribute to the prevention of supplementary infections or ulcers in the diabetic foot.

Keywords : Silver nanoparticles; Onychomycosis; Antifungal agents; Diabetic foot.

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