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Revista Médica del Uruguay

Print version ISSN 0303-3295On-line version ISSN 1688-0390


PERDOMO, William Flórez et al. Progesterone to treat severe traumatic brain injury: a systematic review and meta-analysis. Rev. Méd. Urug. [online]. 2020, vol.36, n.1, pp.192-215.  Epub Mar 01, 2020. ISSN 0303-3295.


to systematically review evidence on the administration of progesterone after a traumatic brain injury in adults and its relationship with mortality and neurological head prognosis.

Inclusion criteria:

randomized clinical trials that include: patients older than 12 years old, having had an injury (Glasgow <8), comparing the administration of Progesterone versus the control group (placebo or no administration).


we searched the following databases: MEDLINE, the Central Register of Controlled Trials (CENTRAL); PubMed, HINARI, EMBASE; Cochrane Injury Group and reference list of articles.


there was no reduction in mortality in patients in the control group (RR 0.93, 95% CI 0.79-1.10 p = 0.41), there were no differences between progesterone and the control group in favorable or adverse neurological outcomes (RR 1.07, 95% CI: 0.97-1.17 p = 0.20, RR 0.94, 95% CI: 0.81 -1,08 p= 0.27), respectively.


there is no evidence that the administration of progesterone after a traumatic brain injury reduces or improves neurological results, although further good quality studies are required to obtain conclusive results.

Keywords : Traumatic brain injuries; Progesterone; Meta-Analysis.

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