SciELO - Scientific Electronic Library Online

vol.35 issue3HIV-related mortality in Uruguay: profle of people who died of AIDS in 2014 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links


Revista Médica del Uruguay

Print version ISSN 0303-3295On-line version ISSN 1688-0390


PEREZ SARTORI, Graciela et al. HIV-associated neurocognitive disorders. Preliminary data of a prospective cohort in uruguay. Rev. Méd. Urug. [online]. 2019, vol.35, n.3, pp.5-30.  Epub Sep 01, 2019. ISSN 0303-3295.


the incidence of mild and moderate neurocognitive disorders (NCDs) in HIV patients continues to increase in spite of antiretroviral therapy (ART). Only a few studies in the region focused on HIV associated NCDs.


to describe the characteristics of NCDs patients, identify posible etiologies and decide whether to start the search.


transversal study with a prospective collection of data. HIV positive patients between 18 and 60 years old with no structural defects of the central nervous system (CNS) were consecutively recruited. Laboratory tests were applied as well as screening for CNS, the Instrumental activities of daily living (IADLs) scale, the International HIV Dementia Scale (IHDS), and the Adenbrooke’s Cognitive Examination revised exam (ACE-R). The latter was chosen as the reference test for neurocognitive performance. The Beck Depression inventory (BDI) was used to identify drepression. Statistical analysis was conducted with the SPSS system.

Results and discussion:

20 patients were recruited, NCD was diagnosed in 9 out of 20 patients (45%). Treating physicians spoke about NCD in 2 of the 9 patients. Multivariate analysis revealed an association between unemployment (p=0.012) and a lower schooling rate (p=0.035) in patients with NCDs. Etiology of NCD was multifactorial in all 9 patients. 8 out of 9 patients were referred as NCDs in the screening. IHDS was appropriate to identify severe NCDs, although it failed in mild cases. Also, IADLs failed to identify a few cases of NCDs.


almost half of the patients presented multifactorial NCDs, associated to unemployment and a lower rate of schooling. Treating physicians did not consider this diagnosis, what reflects the importance of a systematic neuropsychological assessment in HIV patients.

Keywords : HIV-associated neurocognitive disorders; Neurocognitive disorders; AIDS dementia complex; HIV.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )