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Revista Médica del Uruguay

On-line version ISSN 1688-0390


SPERANZA, Noelia et al. Consumo de benzodiazepinas en la población uruguaya: un posible problema de salud pública. Rev. Méd. Urug. [online]. 2015, vol.31, n.2, pp.112-119. ISSN 1688-0390.

Abstract Objective: To quantify and evaluate benzodiazepines consumption in Uruguay between 2010 and 2012. Method: A study of utilization of drugs was conducted to assess benzodiazepines consumption in our population. Drug utilization data refers to oral benzodiazepines dispensed by the pharmacy departments from the participating health institutions. The unit of measurement was the defined daily doses (DDD) per 1000 inhabitants per day (DHD). DHD of hypnotic and anxiolytic benzodiazepines and DHD from public and private health care institutions were compared. Results were described as absolute values and percentage of changes. Results: Sixty two percent of the Uruguayan population was included in the study. Global DHD for 2010, 2011 and 2012 were 74.97, 75.17 and 71.14 (mean 73.76) DDD/1000 inhabitants/day respectively. Alprazolam was the most widely consumed anxiolytic benzodiazepine (mean 25.09) and flunitrazepam was the most commonly consumed hypnotic benzodiazepine (mean 18.69). If clonazepam is included, it becomes the most commonly consumed benzodiazepine (mean 36.51) and global DHD increases up to 106.36, 110.86 and 113.61 (mean 110.28) DDD/1000 inhabitants/day respectively. Clonazepam showed the higher consumption increase from 2010 to 2012 (35.29%), while the use of midazolam (-46.15%) and diazepam (-18.83%) gradually decreased. Public health institutions were responsible for most of the general consumption, whereas private institutions showed the higher increase in benzodiazepines consumption during the evaluated period. Conclusions: Uruguay showed high benzodiazepines consumption, similar to that reported by other countries and it seems to be an issue of public health concern. These are the first available benzodiazepines consumption data in our country and will be useful to perform future comparisons.


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