SciELO - Scientific Electronic Library Online

 
vol.28 issue4Análisis de sobrevida según perfil biológico de pacientes uruguayas con cáncer de mamaComités de Tumores en Uruguay: ¿Cuál es el estado de situación diez años después? author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Related links

Share


Revista Médica del Uruguay

On-line version ISSN 1688-0390

Abstract

RODRIGUEZ, Robinson et al. Glioblastoma multiforme cerebral hemisférico: análisis de sobrevida de 65 casos tratados en el Departamento de Oncología del Hospital de Clínicas, desde 1980 a 2000. Rev. Méd. Urug. [online]. 2012, vol.28, n.4, pp.250-261. ISSN 1688-0390.

Summary Introduction: glioblastoma multiforme (GBM) is the most agressive kind of gliomas. The 5-year survival rate for exclusive surgical treatment is null. Additional chemotherapy and radiotherapy increases survival. Objective: to evaluate the impact of treatment in the survival of patients suffering from GBM. Method: patients with a histological diagnosis of GBM who were seen at the Neuro-Oncology Unit of the Clínicas Hospital, from 1980 through 2000. Clinical, paraclinical and patronymic data was collected, the same as information on the evolution of medical records. Survival rates were calculated through the Kaplan Meier and Mantel Cox method. Results: 65 patients with an average age of 58 years old were studied, (range: 6-79). All of them underwent surgery (complete in 22 patients, subtotal in 9, partial in 32 and biopsy in 2 patients). Ninety two percent of patients were treated with radiotherapy and 25% with chemotherapy. Median survival was 46.6 weeks and global survival one year after was 28%. The probability for survival one year after was 0 in patients who were treated only with surgery; 0.23 in those who also received radiotherapy and 0.62 with chemotherapy QT (p=0,0001). Multivariable analysis identified the following independent variables: multimodal treatment including chemotherapy (p=0,003) and a good postoperative general condition (p=0,007). Conclusions: median survival in this series was similar to that described in literature, there existing a longer survival rate for patients with a good neurologic condition who are treated with radiotherapy and chemotherapy after surgery.

Keywords : GLIOBLASTOMA [therapy]; SURVIVAL ANALYSIS.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License