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Revista Médica del Uruguay

On-line version ISSN 1688-0390


CARDINAL, Pablo; RIEPPI, Gloria  and  BENGOCHEA, Milka. Medicina genómica aplicada a la neumonía aguda comunitaria. Rev. Méd. Urug. [online]. 2011, vol.27, n.1, pp.42-49. ISSN 1688-0390.

Summary Lower respiratory tract infections constitute a serious problem for humanity. Community-acquired pneumonia is the main respiratory disease due to frequency and severity. In spite of progress made by modern medicine, mortality and morbility rates remain unchanged. Response to an infectious attack is strictly personal as it is influenced by the host's genetic structure. Genomic medicine aims to personalize and optimize diagnosis, prognosis and treatment by acknowledging the influence of certain genetic variations, called polymorphisms, on susceptibility and the evolution of several pathologies. Genetic polymorphisms are able to modify the risk of suffering a certain event or episode in a specific disease and being aware of this enables personalizing the interaction between the environment and the host. The present study describes polymorphisms that are positively associated to the evolution of acute-community acquired pneumonia and the possible clinical applications by genomic medicine.


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