SciELO - Scientific Electronic Library Online

vol.24 issue1Factores pronósticos en radioterapia del cáncer de próstata. Importancia de la dosis y de la hormonoterapia de inducciónCADASIL: comunicación de una familia uruguaya con definición clínica, imagenológica, anatomopatológica y genética molecular author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links


Revista Médica del Uruguay

On-line version ISSN 1688-0390


TOLEDO, Nelson et al. Monitoreo de anticuerpos HLA en insuficientes renales crónicos en lista de espera uruguaya para trasplante renal 2005. Rev. Méd. Urug. [online]. 2008, vol.24, n.1, pp.15-23. ISSN 1688-0390.

Summary Introduction: tests of Human Leucocyte Antigen (HLA), antibodies for patients on the waiting list for renal transplant, are necessary to allocate organs and to define the appropriate immunomodulator treatment that result in the best tranplant survival rates. Methods: we looked for HLA antobodies in 488 patients on the national waiting list for renal transplant. We defined patients with reactivity > 20% (41 pacients) as immunized, and those with reactivity > 80% (6 patients) as highly immunized, by using the microlymphocitotoxicity technique against a lymphicyte test panel, detecting specificity by ELISA and flow cytometry Results and conclusions: we found HLA antibodies class I and class II by ELISA ,and identified HLA specificities by flow cytometry: 41 (8.4%) of immunized patients showed HLA antibodies class I and 22 (4.5%) evidenced class II. The most frequently found specificities for these antibodies were : A24, A23, BW6, B44, CW6, CW2, DR8, DR7, DQ2, DQ7.We compared the distribution by age, sex, retransplantation, blood type, previous blood transfusions, time on the waiting list and diagnosis of the immunized population with those non-immunized. We found that in the immunized group most of them are candidates for a second transplant (X2=130,47), have received previous transfusions (X2=119,2) and have been on the waiting list longer(p<0,0001). NO differences were found in the distribution by age, sex or etiological diagnosis of chronic renal failure (CRF), being the non-determined nephropaty and glomerulopathies, the most frequent types. Distribution by blood type showed significant differences: in the immunized group there were more patients belonging to group 0 (X2 =7,9) and less of them belonging to group A (X2 =3,94).


        · abstract in Spanish | French | Portuguese     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License