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Revista Médica del Uruguay

On-line version ISSN 1688-0390

Abstract

GUTIERREZ, Stella et al. Dislipemia y lipodistrofia en niños uruguayos vih positivos en tratamiento antirretroviral. Rev. Méd. Urug. [online]. 2006, vol.22, n.3, pp.197-202. ISSN 1688-0390.

Summary Background. Survival of HIV infected patients has improved with Hightly Active Anti-Retroviral Therapy but adverse effects have come out. Our aim is to describe lipodistrophy and dyslipidemia in HIV infected children under treatment; and to lypodistrophy - dislipidemia/stage of disease - length of treatment. Methods. The transversal descriptive study defines lipoatrophy as infant with normal body mass index (BMI/IMC) and tricipital skin-fold thickness < 5p or sunken cheeks or both; lipohypertrophy as normal body mass index and subscapular skin-fold > 90p or central fat disposition; combined lipodystrophy when both are present. Hypertriglyceridemia and hypercholesterolemia were defined as > 90p according to tables of reference. Length of treatment was classified as < 5 years and stage of disease. Results were expressed as percents, CI 95%. We used the c2 test. Results. Sixty children aged 6.8 + 3.3 years were included in the study. Lypodystrophy was seen in 13 (21.7%, CI 95% 12.5-34.5) and dyslipidemia in 33 (55%, CI 95% 41.7-67.7). Neither dyslipidemia nor lipodystrophy were associated with stages of the disease. Combined dyslipidemia was predominant in children under at least 5 years of treatment, which was different in cases of hypertrigly-ceridemia. Lipodystrophy was not associated with length of treatment. Conclusions. Lipodystrophy and dyslipidemia are frequent alterations. Lipid monitoring and body composition are essential to bring up healthier children.

Keywords : LIPODISTROFIA [ epidemiología]; DISLIPIDEMIAS [ epidemiología.]; INFECCIONES POR HIV [ quimioterapia].

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