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Revista Médica del Uruguay

Print version ISSN 0303-3295On-line version ISSN 1688-0390


OTERO, Ana María et al. D-dímeros ELISA en el control biológico de los tratamientos con heparina de bajo peso molecular del embarazo. Rev. Méd. Urug. [online]. 2006, vol.22, n.1, pp.52-58. ISSN 0303-3295.

Summary The condition of pregnant women with thrombophilia under low molecular weight heparin (HBPM) is special, there are few studies on D-dimer levels in patients cursing pregnancy with no complications. This retrospective study aims at: a) to show expected levels of D-dimer Elisa in women cursing the first three months of pregnancy under HBPM treatment with no complications and successful pregnancy, and b) to show D-dimer Elisa as warning signs of obstetric complications. The study included 113 women with proved trombophile and a risk obstetric history cursing pregnancy under HBPM treatment with no complications and successful pregnancy. They were all monthly controlled with D-dimer ELlSA. Results showed that levels of D-dimer ELlSA significantly increased as pregnancy developed. Cut-points for the different "kit" are useful to assess hemostasis, specially during the second and third months when women under HBPM treatment reached those cut-points. Median and 10 and 90 percentil were calculated for each react, different curves were considered in order to determine D-dimer levels during pregnancy under HBPM treatment. A 90 percentil cut-point is suggested for each react. D-dimer ELlSA high levels might suggest the need of therapeutic measures to prevent obstetric complications as it is seen in four patients discussed in the paper.


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