Resumen

AGUIRRE, Rafael. Perfil clínico y resultados de la hormonoterapia de reemplazo en la población hospitalaria uruguaya. Rev. Méd. Urug. [online]. 2003, vol.19, n.1, pp.53-65. ISSN 1688-0390.

Summary Perimenopausal alterations constitute nowadays an important public health issue. Hormone replacement therapy (HRT) has allowed treating perimenopausal symptoms and preventing long-term outcome due to hormonal deficiency. Objective: to optimize HRT in Public Health users (Ministerio de Salud Pública, MSP) through the analysis of its characteristics and results. Methods: we undertook a longitudinal, observational and prospective study. Two-side analysis and a level of 5% by means of t-test for independent samples and paired t-test for matched data according to the variable in question were used. Results: characteristics of Uruguayan population did not differ from those described by international studies. A statistical significant change of clinical symptoms occurred, lipid profile improved and body weight lightly was increased with HRT. Only 5% of the studied women were excluded because of side effects. One third of the population stopped treatment without medical indication. Conclusions: public Health users presented adequate tolerance, clinical and paraclinical responses to HRT. Accurate information and continue drug availability is needed in order to improve accessibility and completion of a therapy mainly based on prevention.

Palabras clave : TERAPIA DE REEMPLAZO DE ESTRÓGENO; CLIMATERIO; MENOPAUSIA; ESTUDIOS LONGITUDINALES; URUGUAY [epidemiología].

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