Abstract

VACAREZZA CONSANI, Mariela; VAZQUEZ PEDROUZO, Rodolfo  and  SAVIO LARRIERA, Eduardo. Alteraciones del metabolismo lipídico en pacientes infectados por VIH. Rev. Méd. Urug. [online]. 2003, vol.19, n.1, pp.45-52. ISSN 1688-0390.

Summary The infection by human immunodeficiency virus (HIV) and its ultimate consequence, Acquired Immune Deficiency Syndrome (AIDS) is an important public health problem, considering the incidence and mortality, social aspects and costs. In Uruguay the infection by this retrovirus is characterized as a controlled epidemic with a prevalence of 0.3%. The antiretroviral therapy transformed this pathology into a chronic and controlled disease. However, lipidic metabolism abnormalities have been observed. The prevalence of dislipemia in patients with HIV is unknown in our country. This study aimed at comparing the prevalence of lipidic metabolism alterations between patients with HIV and seronegative patients. Other specific objectives included the determination of lipidic alterations in patients with HIV and the associations between antiretroviral therapy drugs and lipidic metabolism complications. A transversal, descriptive study was conducted in two probabilistic samples: 133 patients with HIV and 133 patients of a control group. Statistic significance of the differences was analyzed by calculations of chi-square. In accordance with other studies we concluded that infection by HIV, antiretroviral therapy and antiretroviral drugs caused lipidic metabolism complications. Protease inhibitors such as ritonavir and indinavir caused the most severe lipidic alterations.

Keywords : LIPIDOS [metabolismo]; SINDROME DE INMUNODEFICIENCIA ADQUIRIDA [quimioterapia]; INFECCIONES POR VIH.

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