Abstract

QUIAN, Jorge et al. Transmisión madre-hijo del VIH según quimioprofilaxis recibida, vía de nacimiento y amamantamiento. Rev. Méd. Urug. [online]. 2002, vol.18, n.3, pp.265-269. ISSN 1688-0390.

Summary HIV positive mothers and their children born between 1st January 1995 and 30th June 2000 were studied. Objective. To analyze HIV mother-to-child transmission related to prophylactic therapy, delivery mode and breastfeeding. Methods. Children were categorized as infected, serum-reverted or exposed. Three groups were established: A) without prophylactic therapy, B) zidovudine (ZDV) during pregnancy, labor or cesarean and newborn of at least 42 days old, C) more than one antiretroviral drug during pregnancy and ZDV in labor or cesarean, and newborn of at least 42 days old. Infants were considered as breastfed if they had been receiving mother-milk during more than one week. Delivery modes such as labor, elective cesarean or emergency cesarean were analyzed. Birth weight, gestational age and quantity of pregnancies. Results. In the group A eighty-two mother-child pairs were enrolled in the study, of which they were 41 infected infants (50%). Breastfed infants accounted for 42% (34 infants). In relation to delivery mode, vaginal was seen in 58 mothers (70%) and elective cesarean for 7. The group B was composed by 101 mother-child pairs with 5 infected infants (5%). Two infants were breastfed. Vaginal delivery was seen in 62 patients (61%) and there were 29 cesarean of choice (29%), and the group C by 34 pairs of whom 34 infants were serum-reverted, 33 were not breastfed, no data in the other case. Elective cesarean accounted for 26,5%. There were no differences between the three groups on weight, pregnancy age, mother's age or quantity of pregnancies. Conclusions. HIV mother-to-child transmission frankly decrease with antiretroviral treatment. Increase in elective cesarean and no breastfeeding are associated with this condition.

Keywords : TRANSMISIÓN VERTICAL DE ENFERMEDAD [prevención y control]; INFECCIONES POR VIH [transmisión]; INFECCIONES POR VIH [quimioterapia]; QUIMIOPREVENCIÓN; AGENTES ANTI VIH [uso terapéutico].

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